4 research departments
750 employees
45 nationalities
49 research teams
11 ERC laureates
250 publications per year
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Fondation universite de Strasbourg
Monday, November 30th 2015 - 2 p.m.
Pr Jean Gautier

Mechanisms of MYC-driven genomic instability

Thursday, December 3rd 2015 - 10 a.m.
Pr Yusuf Hannun

Neutral sphingomyelinase in the DNA damage response

Friday, December 4th 2015 - 10 a.m.
Pr Hans Schöler

How are Pluri- and Multipotent Stem Cells Induced and Maintained?

Médaille de bronze 2015 CNRS : Evi SOUTOGLOU Médaille de cristal 2015 CNRS : Philippe ANDRE

How to silence a stem cell gene expression program

Heatmaps showing the dynamic regulation of the epigenetic mark H3K27me3 during T cell differentiation (blue and yellow: low and high H3K27me3 levels), and the mRNA expression of the corresponding genes (green and red: low and high expression levels) in WT and Ikaros-deficient mice.

Nov. 9, 2015

The differentiation of different types of blood cells is dependent on complex genetic and epigenetic programs. Attila Oravecz in the team of Susan Chan and Philippe Kastner uncovered a novel epigenetic regulatory mechanism in the early stages of the differentiation of T lympocytes controlled by the Ikaros transcription factor. Published on November 9th in Nature Communications, this study highlights the repressive role of the latter on many specific genes of hematopoietic stem cells. Ikaros recruits Polycomb complex PRC2 to deposit repressive epigenetic marks. This work highlights a new epigenetic repression mechanism that could explain the tumor suppressor function of Ikaros in leukemia.

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RiboStruct : a new spin-off from IGBMC

From left to right: Marat Yusupov, Gulnara Yusupova and Jean-Paul Renaud

Nov. 5, 2015

One year after the publication in Nature of 16 crystallographic structures of the yeast 80S ribosome in complex with various inhibitors by the teams of Marat Yusupov and Gulnara Yusupova, the RiboStruct start-up project led by Jean-Paul Renaud has now materialized.

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Amphiphysin: a key hub for nuclear positioning

The BIN1 gene (encoding for amphiphysin) is regulating the positioning of the nucleus through several proteins related to the cytoskeleton: amphiphysin binds to nesprin, an actin interactor, and directly to actin filaments. Amphiphysin also partners with CLIP170, a microtubule-associated protein.

Oct. 26, 2015

The place of the nucleus is important for the organization of cells and tissue development. This positioning is altered in many diseases such as centronuclear myopathies. In a study published on October 26th in Developmental Cell, the teams of Jocelyn Laporte and Michel Labouesse, in collaboration with those of Edgar Gomes in Lisbon and Vincent Gache in Lyon, have just identified a key player in the nucleus positioning mechanism: the amphiphysin.


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TARDIS: a universal method at everyone hands to identify rare RNAs

Schematic overview of TARDIS and its modular workflows.

Oct. 29, 2015

During the last years, RNA sequencing has become a widely used tool to study RNA expression. However, a cost-effective and universal protocol capable of dealing with any source of input RNA was not available till date. In a study coordinated by Maximiliano Portal and Hinrich Gronemeyer at the IGBMC, the scientists have developed a method for RNA-sequencing library preparation that is capable of querying the entire transcriptome of any organism, regardless of RNA length, function, the presence or absence of poly-A or biogenesis mechanism. Called TARDIS (for Targeted Directional Sequencing RNA), this protocol was published on October 29th in the journal Nature Protocols.

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Université de Strasbourg

IGBMC - CNRS UMR 7104 - Inserm U 964
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