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Model of signal transduction propagation and gene regulatory networks involved in cell differentiation after retinoic acid treatment. The starting node where the initial cue activates the signal transduction is depicted, as well as the downstream node interconnections required for its propagation. The temporal transcriptional state for each gene (node) is defined as 1, 0 or -1 (up-regulated, non-responsive or down-regulated respectively).
Sept. 20, 2016
By using the integration of multiple functional genomic read-outs, Hinrich Gronemeyer’s team has modeled stem cell fate through the reconstruction of gene regulatory networks involved in this process.
In this work published on September 20th in Genome Research, the authors achieved to modify cell fate by activating some key genes identified through computational modeling. Such integrative approach will surely generate valuable predictions for regenerative medecine.
Left panel : normal migration of neurons (yellow).
Right panel : neurons remain blocked around ventricles.
Oct. 3, 2016
The team of Jamel Chelly at the IGBMC has just identified a new gene involved in a type of brain malformation affecting the development of the brain: the periventricular nodular heterotopia. Their research are published since October 3th, 2016 in the journal Nature Genetics.
3D imaging can reveal more precisely the complexity of embryonic development in mice with viable solutions to genetic analysis of broadband to understand gene function.
Sept. 22, 2016
As part of the International Mouse Phenotyping Consortium, the French National Infrastructure for mouse phenogenomics, PHENOMIN hosted by the Mouse Clinical Institute (IGBMC, UMR7104 CNRS, INSERM, and University of Strasbourg) has coordinated its efforts with 17 other centers to reveal the important role of almost 1 out of 4 genes for controlling normal development of the mouse embryo. These results were published in Nature on September 22th.