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Médaille de bronze 2015 CNRS : Evi SOUTOGLOU Médaille de cristal 2015 CNRS : Philippe ANDRE
Schema of the functions and actions of PGC-1β in a muscle and its interest in muscle performance.
Dec. 17, 2015
The PGC-1α and PGC-1β transcriptional co-regulators are known to be involved in energy metabolism. While PC-1α is already well studied, only few data on the pathophysiological role of PGC-1β are available. In a new study published on December 17th 2015 in the journal Nature communications, the researchers of Daniel Metzger’s team were able to inactivate specifically PGC-1β in muscle fibers of adult mice. The results obtained in collaboration with the teams of Bernard Geny and Arnaud Ferry, show that this co-regulator is essential for optimal mitochondrial activity in the cells.
UBASH3B is a critical factor for recruitment of Aurora B to mitotic microtubules, thereby controlling the speed and accuracy of chromosome segregation during human cell division.
Jan. 11, 2016
Cell division, known as mitotic division, is essential for the development of multicellular organisms from a single cell. Dysregulation of this process may contribute to the development of human cancers. Ubiquitin is a small protein that is conserved in eucaryotic cells. Ubiquitylation is a process in which one or more ubiquitin molecules are attached to target proteins. Ubiquitylation is a very versatile modification that can trigger degradation of the target protein or alternatively regulate its function. The plethora of different ubiquitin tags create a so called ubiquitin code. However, it remained unexplored how this code is read out during mitosis in human cells.
From left to right: Marat Yusupov, Gulnara Yusupova and Jean-Paul Renaud
Nov. 5, 2015
One year after the publication in Nature of 16 crystallographic structures of the yeast 80S ribosome in complex with various inhibitors by the teams of Marat Yusupov and Gulnara Yusupova, the RiboStruct start-up project led by Jean-Paul Renaud has now materialized.
TNKS1 is recruited to DNA repair foci (green spots) that colocalize with the DNA damage response marker γ-H2AX (red spots). The recruitment depends on MDC1, as in MDC1 depleted cells TNKS1 does not form DNA repair foci (green diffused signal).
Feb. 4, 2016
Different damaging agents like exposure to UV or environmental chemicals continuously challenge the integrity of our genome. When the DNA breaks, a cascade of proteins is assembled at each lesion to signal its presence and to ensure proper DNA repair. Since the discovery of DNA repair pathways that was awarded by the Nobel Prize for Chemistry last year, a plethora of signaling and DNA repair proteins have been identified and characterized. One of these proteins is called MDC1 (The mediator of the checkpoint 1). MDC1 amplifies the signals emitted by the DNA lesions and leads to cell cycle arrest until the breaks are repaired. This protein is also essential for repairing the DNA lesions. Despite the fact that the role of MDC1 in DNA repair is well known, how it exert its function is not understood.