4 research departments
750 employees
45 nationalities
55 research teams
16 ERC laureates
260 publications per year
24000 m² lab area

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Fondation universite de Strasbourg
Wednesday, November 2nd 2016 - 11 a.m.
Dr Prem Premsrirut

RNAi and CRISPR/Cas9 Advanced Models for Drug Discovery

Tuesday, November 8th 2016 - 1:30 p.m.
Pr Paul Saftig

Lysosomal membrane proteins – Emerging functions

Thursday, November 10th 2016 - 11 a.m.
Dr Peter Fraser

3D Dynamics of Genome Architecture

The power of cell fate modeling

Model of signal transduction propagation and gene regulatory networks involved in cell differentiation after retinoic acid treatment. The starting node where the initial cue activates the signal transduction is depicted, as well as the downstream node interconnections required for its propagation. The temporal transcriptional state for each gene (node) is defined as 1, 0 or -1 (up-regulated, non-responsive or down-regulated respectively).

Sept. 20, 2016

By using the integration of multiple functional genomic read-outs, Hinrich Gronemeyer’s team has modeled stem cell fate through the reconstruction of gene regulatory networks involved in this process.
In this work published on September 20th in Genome Research, the authors achieved to modify cell fate by activating some key genes identified through computational modeling. Such integrative approach will surely generate valuable predictions for regenerative medecine.

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Periventricular nodular heterotopia: a new gene involved in this disease

Left panel : normal migration of neurons (yellow).
Right panel : neurons remain blocked around ventricles.

Oct. 3, 2016

The team of Jamel Chelly at the IGBMC has just identified a new gene involved in a type of brain malformation affecting the development of the brain: the periventricular nodular heterotopia. Their research are published since October 3th, 2016 in the journal Nature Genetics.

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Gene function: solving the puzzle is on the right track

3D imaging can reveal more precisely the complexity of embryonic development in mice with viable solutions to genetic analysis of broadband to understand gene function.

Sept. 22, 2016

As part of the International Mouse Phenotyping Consortium, the French National Infrastructure for mouse phenogenomics, PHENOMIN hosted by the Mouse Clinical Institute (IGBMC, UMR7104 CNRS, INSERM, and University of Strasbourg) has coordinated its efforts with 17 other centers to reveal the important role of almost 1 out of 4 genes for controlling normal development of the mouse embryo. These results were published in Nature on September 22th.



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Université de Strasbourg

IGBMC - CNRS UMR 7104 - Inserm U 964
1 rue Laurent Fries / BP 10142 / 67404 Illkirch CEDEX / France Tél +33 (0)3 88 65 32 00 / Fax +33 (0)3 88 65 32 01 / directeur.igbmc@igbmc.fr