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Prix Alexandre Joannidès 2014 Académie des sciences : Irwin DAVIDSON
Oct. 1, 2014
Upper panel: Section through a normal liver. The cell membranes are well delimited (in green) and normal bile ducts (BD) are formed.
Lower panel: Section through a liver lacking TAF4. The cell membranes are less well delimited (in green), and the bile ducts are defective (dBDs) and do not form a proper lumen to drain the bile from the liver.
Oct. 3, 2014
The group of Irwin Davidson have discovered a novel role for the TAF4 protein in hepatocyte maturation opening the way to understanding its eventual role in diabetes. The results are published by Alpern et al., on 3 October in eLife.
While the amount of total mRNA seemed little affected when SAGA is inhibited (bottom), the net production of new mRNA in the mutants is drastically reduced on all the genes (top).
Sept. 15, 2014
A study coordinated by Didier Devys in Làszlò Tora’s team at the IGBMC highlights the crucial role of the SAGA coactivator complex in the transcription of our genes, largely underestimated so far. Indeed they proved that it has a role throughout the entire transcribed genome and is essential for proper functioning of the RNA polymerase II. These results are published on September 15th in the journal Genes & Development.
According to the location of damaged genes in the nucleus, the cell is able to trigger different and adapted repair mechanisms.
Nov. 3, 2014
The double-strand DNA breaks are particularly dangerous. The research team of Evi Soutoglou at IGBMC has just discovered that the choice of natural repair mechanisms of the cell, in response to this type of injury, depends on the location of genes in the nucleus. These results are published on the 3rd of November in the journal Genes & Development.
At the top: Helical structure of the polyribosome, in blue the 60S subunits facing outwards. At the bottom : Details of protein interactions between the exit site of the mRNA at a ribosome (i), and the entry site of the mRNA on the following ribosome (i + 1). These details show a continuity of the channel that contains the mRNA (red dotted line), from a ribosome to another without forming loops, which allows it to be protected inside.
Nov. 7, 2014
Key elements of protein synthesis, ribosomes are sometimes positioned like beads on a string on the messenger RNA to amplify the effectiveness of translation. While little information was available about the precise structure of this assembly, microscopists and crystallographers of Bruno Klaholz’s team managed to determine its precise configuration in 3 dimensions, providing new information on the mechanisms of translation. These results are published November 7th in the journal Nature Communications.