Coordinated regulation of gut microbiome and immune checkpoint activity by the ubiquitin ligase RNF5
Pr Ze'ev RONAI
Technion Integrated Cancer Center, Israel Institute of Technology, Haifa, Israël
mercredi 14 mars 2018 - 16h00
- Auditorium, IGBMC
Invité(e) par Irwin DAVIDSON
The ubiquitin ligase RNF5 has been implicated in the regulation of ER stress, autophagy and glutamine metabolism. Inoculation of melanoma cells in RNF5 KO mice resulted in limited growth, indicating that lack of RNF5 results in effective inhibition of melanoma development. We found that RNF5 limits melanoma growth by coordinating gut microbiome and immune checkpoint activity. How RNF5 affects the gut microbiome and concomitantly - anti tumor immune response, will be discussed.