4 research departments
750 employees
45 nationalities
49 research teams
11 ERC laureates
250 publications per year
24000 m² lab area

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Key figures

52 research teams
130 researchers
118 post-doctoral fellows
104 PhD students
201 engineers & technicians
4 master students
117 administrators & general services

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Organisation

  • IGBMC executive board

    DIRECTOR

    Bertrand Séraphin

    DEPUTY DIRECTOR

    Yann Hérault

    SCIENTIFIC DIRECTION COMMITTEE

    Scientific affairs direction

    Astrid Lunkes

    Scientific departments


    Development & Stem Cells

    Pascal Dollé

    Integrated Structural Biology

    Patrick Schultz

    Functional Genomics & Cancer

    Irwin Davidson

    Translational Medicine & Neurogenetics

    Hélène Puccio

    TECHNOLOGY PLATFORMS AND SCIENTIFIC SERVICES

    INFRASTRUCTURES


    Mouse Clinical Institute


    Yann Hérault

    Integrated Structural Biology


    Bruno Klaholz

    SUPPORT SERVICES

    Administrative and Financial direction

    Katell Morvan

    Direction of scientific and logistical operations

    Nicolas Bensel

    Bertrand Seraphin

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    IGBMC Director

    Bertrand SERAPHIN

     

    After studying at the ENS, B. Seraphin obtained his PhD in 1988 at Curie Institute (Orsay) on mitochondrial splicing. From 1987 to 1989, as a post-doctoral fellow at Brandeis University (Boston) with Pr. M. Rosbash, he studied yeast nuclear splicing and brought to light new splicing complexes. In 1991, he joined I. Mattaj at EMBL before becoming an independent team leader. His group elucidated steps of splicing and RNA maturation, identifying numerous new factors on the way in part with the help of the newly developped TAP method. He received the Silver Medal of the CNRS in 2007 and is nominated for "Inventor of the Year 2008" by the European Patent Office. In 2000, he integrated the CGM (Gif/Yvette) where he studied RNA decay, discovering new enzymes, an uncharacterized cellular compartment, and new nonannotated transcripts. His research has been continuing at the IGBMC since 2009.
    Yann Herault

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    IGBMC Deputy Director
    Mouse Clinical Institute Director

    Yann HERAULT

    Yann Herault obtained his PhD on the transcription regulation of clusterin at the ENS in Lyon in 1993. He then became interested in developmental biology and joined D. Duboule's laboratory at the University of Geneva in order to study Hox genes regulation. He became interested in Down's syndrome and created a resource of trisomic mice models for almost the entire Down's syndrome homolog genes in mouse. In 2007, he led the Transgenesis and Archiving of Animal Models unit in Orleans. He joined the IGBMC in 2010 as the director of the Mouse Clinic Institute and since then leads a team aiming at mapping relations between genotypes and phenotype in Down's syndrome. In 2010, he won the Price Young Investigator FRM ALSACE.
    Astrid Lunkes

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    Director of scientific affairs

    Astrid LUNKES

     

    Astrid Lunkes is a scientist by training. She received her PhD in Genetics at the University of Düsseldorf (1995), followed by postdoctoral studies at the IGBMC on pathogenetic mechanisms of Huntington's disease. In 2001, she joined the EMBO Journal as an editor and later on launched the journal Molecular Systems Biology. In 2005, she took up strategic functions at the European Science Foundation (ESF), developing the European research landscape with European and International stakeholders. She joined IGBMC in 2009 as Director of Scientific Affairs.
    Pascal Dolle

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    Department director

    Development & Stem Cells

    Pascal DOLLE

    Patrick Schultz

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    Department director

    Integrated Structural Biology

    Patrick SCHULTZ

    Patrick Schultz gained a background in molecular biology and genetics at the University Louis Pasteur and pursued his academic career by a thesis on chromatin organization under the direction of P. Oudet (1987). After an internship at EMBL, he started a post-doctoral fellowship at LGME (Strasbourg) and oriented his research towards the structural investigation of molecular complexes involved in transcription. In 1991, he determined the first three-dimensional model of RNA polymerase I by electron microscopy. He joined the newly created IGBMC in 1994 to solve the molecular organization of general transcription factors (TFIIH, TFIIE, and TFIID) as well as of co-activators (TFIID and SAGA). Since then, he works on a better understanding of the structure and the assembly modes of transcription initiation complexes and on the mechanisms of regulatory signal transduction.
    Irwin Davidson

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    Department director

    Functional Genomics & Cancer

    Irwin DAVIDSON

    After obtaining his PhD at the University of Glasgow on the herpes virus in 1985, he became a post-doctoral fellow at the LGME, the forerunner of the IGBMC in Strasbourg, working on the identification of transcription factors interacting with the SV40 enhancer. In 1990, he became principal investigator, is interested in the mechanisms of transcription activation and participated in the identification of the TFIID factor and its role as a coactivator in 1993. In 2000, he began to study TBP and its paralogue TRF2 in mouse, where he demonstrated the specific role of TRF2 in transcription regulation in male germ cells. His group also characterized the structure and functions of TAF4 and revealed its role in various signaling pathways. In addition, the group currently studies the role of transcription factor MITF and its cofactors in malignant melanoma.
    Helene Puccio

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    Department director

    Translational Medicine & Neurogenetics

    Hélène PUCCIO

    After obtaining her PhD in Genetics from Harvard University, USA in 1998, Hélène Puccio joined the group of M. Koenig at the IGBMC to work on the molecular pathogenesis of Friedreich ataxia (FRDA). In 2001, she was appointed Inserm research associate and has since been the principal investigator on the FRDA project. In 2008, she was promoted Inserm Research Director (DR). Her research interest focuses on understanding the pathophysiological mechanisms implicated in recessive ataxias linked to mitochondrial dysfunciton. She was awarded the Pediatric Pathology Prize in 2005 and also received the label "Equipe FRM". In 2007, she obtained the prestigious Young Investigator ERC award, and in 2008 she received the Dr. Jean Toy Prize from the French Academy of Sciences.
    Philippe Kastner

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    Scientific coordinator

    Platforms & Scientific services

    Philippe KASTNER

    Bruno Klaholz

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    Scientific coordinator

    FRISBI (French Infrastructure for Structural Biology)

    Bruno KLAHOLZ

    The research of his team focuses on the study of complexes involved in the regulation of gene expression, particularly at the level of transcription and translation. The research axis on transcription focuses on the function of chromatin remodelling complexes and on nuclear receptors which represent important therapeutic targets. The research axis on translation concerns the mechanism of protein biosynthesis catalyzed by the bacterial and eukaryotic ribosomes. With a strong background in crystallography and cryo electron microscopy acquired during his PhD and then during his postdoc, his group group aims at analyzing various structural and functional states of these large macromolecular complexes by using an integrated structural biology approach to obtain insights into the mechanisms of gene regulation which provide the molecular basis for the development of new drugs.
    Katell Morvan

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    Administrative and Financial director

    Katell MORVAN

     

    K. Morvan graduated from a top business school and occupied several administrative positions in diverse fields before joining the world of research. In 1990, she joined bio-medical analysis laboratories at the Faculty of Medicine in Strasbourg. She became administrative and financial Director of the IGBMC in 1995 and participated in 2002 in the creation of the Mouse Clinical Institute and the Economic Interest Grouping - European Centre of Research in Biology and Medicine (CERBM - GIE).
    Nicolas Bensel

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    Scientific and logistical operations director

    Nicolas BENSEL

     

    N. Bensel received his PhD in bioorganic chemistry in german-speaking Switzerland and then completed a 2-year postdoctoral fellowship at the University of California, Berkeley. He is also the co-founder of the NovAlix company, specializing in provision of research for the pharmaceutical, cosmetics and fine chemistry industries. He joined the IGBMC in March 2010.

Imprimer Envoyer

Université de Strasbourg
INSERM
CNRS

IGBMC - CNRS UMR 7104 - Inserm U 964
1 rue Laurent Fries / BP 10142 / 67404 Illkirch CEDEX / France Tél +33 (0)3 88 65 32 00 / Fax +33 (0)3 88 65 32 01 / directeur.igbmc@igbmc.fr