Post Doc - Equipe Y.Trottier
Reference : Post-doc Y.T.
Publication de l'offre : 15 mars 2016
Our laboratory is focused on understanding the pathomechanisms implicated in neurodegenerative polyglutamine expansion diseases. Progress in this field relies on innovative and predictive disease models for which there is an urgent need for mechanistic and preclinical studies. The Joint Program Neurodegenerative Disease Research (JPND) is supporting an european collaborative network to develop and characterize genetically-modified rodent models and induced pluripotent stem cells for polyglutamine disorders.
We are offering a JPND-funded fellowship for post-doctoral studies on disease models of SpinoCerebellar Ataxia 7 (SCA7), a polyglutamine disease that causes adult-onset progressive degeneration of cerebellar neurons and retinal photoreceptors, leading to ataxia and blindness. The project aims at improving our understanding of the pathomechanism by correlating specific and refined phenotypic evaluation, neuropathology and « omic » data on new SCA7 mice.
Our laboratory is located in the internationally renowned Institute of Genetic and Molecular and Cellular Biology (http://www.igbmc.fr/) in Illkirch-Strasbourg, France, and is embedded in a highly collaborative and multidisciplinary environment. The MouseClinical Institute (http://www.ics-mci.fr/en) (Illkrich) will be our partner throughout the project. The candidate will benefit from an international environment and various state-of–the art technology platforms.
The ideal candidate has a Ph.D. degree and a solid experience in molecular and cellular biology and mouse phenotyping, and strong interest in neurodegenerative disorders. Knowledge on bioinformatic and omic data analysis would be an asset. Applicants should be able to perform experimental research in an independent way and to closely interact with the european network members.
Please send your application (including a motivation cover letter, a CV, a description of research experience and contact information for 2-3 references) by email to Yvon.Trottier@igbmc.fr.
The candidate is expected to start in May/June 2016.