Post Doc - Equipe J.Chelly
Reference : Post doc J.C.
Publication de l'offre : 4 septembre 2018
Post doc in molecular mechanisms of neurodevelopmental diseases
A fully-funded post-doctoral position is available in the group of genetics and pathophysiology of neurodevelopmental and epileptogenic disorders at the Institut de Génétique et Biologie Moléculaire et Cellulaire (IGBMC) in Strasbourg, France. Our team is interested to understand the genetic causes and molecular mechanisms of neurodevelopmental diseases.
The aim of the project will be to dissect the mechanisms underlying neuronal translation control by the Fragile X Mental Retardation protein (FMRP). The project is part of an ANR funded program (2CureXfra) aiming at deciphering the regulation of diacylglycerol kinase (DGKk) by FMRP and its dysregulation in Fragile X syndrome. The goals are to define the molecular mechanism of FMRP translation control of DGKk in neurons and to determine the functional consequences of DGKk deregulation in the mouse and human. The project will involve multidisciplinary approaches including RNA-seq, imaging, ribosome profiling, reporter assays, in cultured cells, primary neurons and animal models.
Ideal candidate should have PhD degree in biochemistry, molecular biology or molecular neuroscience, and interest in RNA biology and mechanisms of gene regulation.
An ability to independently take responsibility over his/her own project, as well as strong teamwork and communication skills, are required as well as reliability, attention to detail and effective time management. Motivation to work in a multidisciplinary and international environment is fundamental to this position. Good communication and presentation skills and fluency in English are expected.
This position is available from January 2019.
The applicant should send her/his curriculum vitae (with a summary of research experience, current research scientific interests, career goals and list of publications), a cover letter discussing her/his interest in the position and stating the date when she/he expects to be available, and contact information for two references to: Dr Hervé Moine