Team leaders :
| Norbert B. GHYSELINCK norbert@igbmc.u-strasbg.fr Tel. +33 (0) 3 88 65 56 74 |
Manuel MARK marek@igbmc.u-strasbg.fr Tel. +33 (0) 3 88 65 56 36 |
Research interests :
We are focusing our efforts on the understanding of the roles played by retinoic acid, the active vitamin A metabolite, and its nuclear receptors in homeostatic and pathological processes, notably stem cell differentiation in the mouse.
| Team certified by the FRM in 2008 |  |
Retinoic acid receptor signalling pathways in mouse development, reproduction and tissue homeostasis
Team members : Permanent scientist(s) :
Norbert B. GHYSELINCK
Manuel MARK
Post-doctoral fellow(s):
Carmen POPESCU
Graduate Student(s):
Hughes JACOBS
Master student(s)
Mathilde RAVERDEAU
Engineer(s)/Technician(s)
Christine DENNEFELD
Betty FERET
Muriel KLOPFENSTEIN
Main publications :
Mascrez, B., Ghyselinck, N.B., Chambon, P., Mark, M. (2009). A transcriptionally silent RXRalpha supports early embryonic morphogenesis and heart development. Proc. Natl. Acad. Sci. USA 106, 4272-4277.
Mark, M., Jacobs, H., Oulad-Abdelghani, M., Dennefeld, C., Féret, B., Vernet, N., Codreanu, C.A., Chambon, P., Ghyselinck, N.B. (2008). STRA8-deficient spermatocytes initiate, but fail to complete, meiosis and undergo premature chromosome condensation. J. Cell Sci. 121, 3233-3242.
Vernet, N., Dennefeld, C., Guillou, F., Chambon, P., Ghyselinck, N.B., Mark, M. (2006). Prepubertal testis development relies on retinoic acid but not rexinoid receptors in Sertoli cells. EMBO J. 25, 5816-5825.
Vernet, N., Dennefeld, C., Rochette-Egly, C., Oulad-Abdelghani, M., Chambon, P., Ghyselinck, N.B., Mark, M. (2006). Retinoic acid metabolism and signaling pathways in the adult and developing mouse testis. Endocrinology 147, 96-110.
Mark, M., Ghyselinck, N.B., Chambon, P. (2006). Functions of retinoid nuclear receptors in mouse embryonic development: lessons from genetic and pharmacological dissections of their signalling pathway. Annu Rev Pharmacol Toxicol 46, 451-480.
Mascrez, B., Ghyselinck; N.B., Watanabe, M., Annicotte, J.S., Chambon, P., Auwerx; J., Mark, M. (2004) Ligand-dependent contribution of RXRbeta to cholesterol homeostasis in Sertoli cells. EMBO Rep. 5:285-290.
Schnutgen F, Doerflinger N, Calleja C, Wendling O, Chambon P, Ghyselinck NB. (2003) A directional strategy for monitoring Cre-mediated recombination at the cellular level in the mouse. Nat Biotechnol. 21, 562-565.
