Team leaders : Daniel METZGER and Pierre CHAMBON
Contacts :
| Daniel METZGER metzger@igbmc.u-strasbg.fr Tél. +33 (0) 3 88 65 34 63 |
Pierre CHAMBON chambon@igbmc.u-strasbg.fr Tél. +33 (0) 3 88 65 32 13 |
Research interests:
Our projects are aimed at elucidating the functions of nuclear receptors, as well as some of their co-factors in skin, in the major organs/tissues involved in energy homeostasis, in the vascular system, bone. Our approach, based on spatio-temporally-controlled targeted somatic mutagenesis in the mouse, a powerful technology developed in our laboratory over the last years, generates valuable mouse models for various human diseases such as obesity, diabetes, osteoporosis, atopic dermatitis as well as skin, colon and prostate cancer.
Team Members : Permanent scientist(s) :
Pierre CHAMBON
Andrée KRUST
Mei LI
Daniel METZGER
Post-doctoral fellow(s):
Mirela NASTASI
Susan PARK
Chandrahas Koumar RATNACARAM
Milan SURJIT
Cristina ANTAL
Graduate Student(s):
Céline CHAMBON
Delphine DUTEIL
Krishma GANTI
Alessandra LANA
Zhikun ZHANG
Engineers/Technicians
Jean-Marc BORNERT
Laetitia FRIEDMANN
Laetitia GARGOWITSCH
Pierre HENER
Magali HUC
Stéphane ROTH
Main publications :
Nakamura T, Imai Y, Matsumoto T, Sato S, Takeuchi K, Igarashi K, Harada Y, Azuma Y, Krust A, Yamamoto Y, Nishina H, Takeda S, Takayanagi H, Metzger D, Kanno J, Takaoka K, Martin TJ, Chambon P, Kato S. (2007) Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts.Cell. 130(5):811-23..
Metzger D, Chambon P. (2007). Contribution of targeted conditional somatic mutagenesis to deciphering retinoid X receptor functions and to generating mouse models of human diseases. Handb Exp Pharmacol.(178):511-24. Review.
Indra AK, Castaneda E, Antal MC, Jiang M, Messaddeq N, Meng X, Loehr CV, Gariglio P, Kato S, Wahli W, Desvergne B, Metzger D, Chambon P. (2007). Malignant transformation of DMBA/TPA-induced papillomas and nevi in the skin of mice selectively lacking retinoid-X-receptor alpha in epidermal keratinocytes. J Invest Dermatol. 127(5):1250-60..
Schuler M, Ali F, Chambon C, Duteil D, Bornert JM, Tardivel A, Desvergne B, Wahli W, Chambon P, Metzger D. (2006). PGC1alpha expression is controlled in skeletal muscles by PPARbeta, whose ablation results in fiber-type switching, obesity, and type 2 diabetes. Cell Metab. 4(5):407-14..
Li M, Hener P, Zhang Z, Kato S, Metzger D, Chambon P. (2006). Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis. Proc Natl Acad Sci U S A. 103(31):11736-41..
Li M, Messaddeq N, Teletin M, Pasquali JL, Metzger D, Chambon P. (2005) Retinoid X receptor ablation in adult mouse keratinocytes generates an atopic dermatitis triggered by thymic stromal lymphopoietin. Proc Natl Acad Sci U S A. 102(41):14795-800..
T. Imai, R. Takakuwa, S. Marchand, E. Dentz, J.-M. Bornert, N. Messaddeq, O. Wendling, M. Mark, B. Desvergne, W. Wahli, P. Chambon and D. Metzger (2004). Peroxisome proliferators-activated receptor g is required in mature white and brown adipocytes for their survival in the mouse. Proc. Natl. Acad. Sci. U. S. A. , 101, 4543 - 4547.
T. Imai, M. Jiang, P. Kastner, P. Chambon and D. Metzger (2001) Selective ablation of RXRa in hepatocytes impairs their lifespan. Proc. Natl. Acad. Sci. U. S. A., 98, 4581 - 4586.
T. Imai, M. Jiang, P. Chambon and D. Metzger (2001) Impaired adipogenesis and lipolysis in the mouse upon Cre-ERT2 -mediated selective ablation of RXRa in adipocytes. Proc. Natl. Acad. Sci. U. S. A., 98, 224 - 228.
W Krezel, S. Dupont, A. Krust, P. Chambon and P.F. Chapman (2001) Increased anxiety and synaptic plasticity in estrogen receptor beta - deficient mice. Proc Natl Acad Sci U S A 98: 12278-82.
S. Dupont, A. Krust, A. Gansmuller, A. Dierich, P. Chambon and M. Mark (2000) Effect of single and compoud knockouts of estrogen receptors α (ERα ) and β (ERβ ) on mouse reproductive phenotypes. Development 127,4277-4291.
M. Li, A. K. Indra, X. Warot, J. Brocard, N. Messaddeq, S. Kato, D. Metzger and P. Chambon (2000) Skin abnormalities generated by temporally controlled RXRa mutations in mouse epidermis. Nature, 407, 633-636.
