IGBMC : Institut de la Génétique et de la Biologie Moléculaire et Cellulaire

• Researchers

  Hinrich GRONEMEYER

• Post-Doctoral Fellowships

  Megan ASTLE

  Marco Antonio MENDOZA PARRA

  Shankara Narayanan PATTABHIRAMAN

  Valeria PAVET-PORTAL

  Maximiliano PORTAL

• Phd Students

  Cathrin SCHULZ

  Jelena VJETROVIC

• Engineers & Technicians

  Cathie ERB

  Michèle LIEB

  Malgorzata NOWICKA

  Judith VALLET

  Wouter VAN GOOL

• Administration

  Irène YUJNOVSKY

Functional genomics & cancer

From nuclear receptor action to novel paradigms for cancer therapy action

Our interest is to understand the mechanisms of signal transduction and epigenetic (de)regulation in normal cells and cancer, which are relevant for the development of novel therapeutic paradigms. Based on our expertise on nuclear receptors we first develop global systems biology approaches to deconvolute receptor signaling complexity and aberrant (epigenetic) signaling upon tumorigenic transformation and study the mechanisms and therapeutic potential of cancer-selective apoptosis pathways induced by various signaling drugs and epigenetic modulators. Our studies involve a plethora of genome-wide technologies and the corresponding development of bioinformatics tools.
One emphasis of our work is to decipher the mechanisms underlying the cancer-selectivity of apoptogenic TRAIL signaling. We use the obtained knowledge to devise novel therapeutic tools and study the contribution of this pathway to the action of (epi-)drugs. Studies on the role of the senescence-mediated secretome on TRAIL action and the epigenetic alterations during cellular senescence address the link between cancer and aging.
Our work benefits from the integration and coordination of several national and European consortia, which provide the necessary multidisciplinary input and a close link to the local hospital (HUS).

Team website

• Current projects

  - A multivalent peptide library approach to identify functional TRAIL mimetics, ApoMULTI-LIB. Project financed by the ANR
  - Molecular analysis of tumor-cell specific apoptosis. Project financed by the Ligue Nationale contre le cancer
  - HEALTH-F4-2007-200767 (APO-SYS) Apoptosis systems biology applied to cancer and AIDS. An integrated approach of experimental biology. Project financed by the European Commission
  - HEALTH-2007- 221952 (ATLAS) Development of Laser-Based Technologies and Prototype Instruments for Genome-Wide Chromatin ImmunoPrecipitation Analyses. Project financed by the European Commission
  - Decryption of the role(s) of methylated CBP/p300 species in signal transduction:  Analysis of methyl-HAT « codes » in differentiation and aberrant HAT methylation in cancer. Project financed by the INCa
  - Identification of modulators and gene expression signatures of TRAIL sensitivity. Project funded by ARC
  - Epigenetic regulation of tumour-cell specific apoptosis. Project financed by the INCa

• Collaborations

  - Dr. Angel de Lera, Professor of Organic Chemistry, Universidade de Vigo, Vigo, SPAIN
  - Dr. Laurence Vandel, Centre de Biologie du Developpement, UMR5547 du CNRS/Universite Paul Sabatier, Toulouse, FRANCE
  - Dr. William Bourguet, Centre de Biochimie Structurale, CNRS UMR5048 / INSERM U1054, Montpellier, France
  - Dr. Raoul Herbrecht, Hôpitaux Universitaires de Strasbourg, Strasbourg, France
  - Dr. Gilles Guichard, Institut Européen de Chimie et Biologie (IECB), Université de Bordeaux I - CNRS UMR 5248, Pessac, France
  - Dr. Sylvie Fournel, PhD, Institut de Biologie Moléculaire et Cellulaire, CNRS UPR 9021, Strasbourg, FRANCE
  - Olivier Micheau, INSERM  U866-Lipides Nutrition Cancer, Facultés de Médecine et de Pharmacie, Dijon, FRANCE
  
  ATLAS: http://www.atlas-eu.com/
  APO-SYS : http://www.apo-sys.eu/

• Prizes/Awards

  • Hinrich GRONEMEYER - Scientific Excellence Award - Inserm - 2010
  • Hinrich GRONEMEYER - European Medal - The Endocrine Society - 1996
  • Hinrich GRONEMEYER - Member of the European Molecular Biology Organization (EMBO) - European Molecular Biology Organization (EMBO) - 1995
  • Hinrich GRONEMEYER - Scientific Prize - Société Française d'Endocrinologie (SFE) - 1991

• News

  • June 6, 2011 - Smaller and smaller samples
  • June 1, 2011 - The oestradiol secret code

• Publications

  • Design and Stereoselective Synthesis of Retinoids with Ferrocene or N-Butylcarbazole Pharmacophores that Induce Post-Differentiation Apoptosis in Acute Promyelocytic Leukemia Cells

    Ivanova D., Gronemeyer H., de Lera A.R.

    ChemMedChem Aug. 1, 2011 ; 6:1518-29 .

  • Epigenetic profiling of the antitumor natural product psammaplin A and its analogues

    Garcia J., Franci G., Pereira R., Benedetti R., Nebbioso A., Rodriguez-Barrios F., Gronemeyer H., Altucci L., Lera A.R.

    Bioorg Med Chem June 15, 2011 ; 19:3637-49 .

  • Methylation specifies distinct estrogen-induced binding site repertoires of CBP to chromatin

    Ceschin D.G., Walia M., Wenk S.S., Duboe C., Gaudon C., Xiao Y., Fauquier L., Sankar M., Vandel L., Gronemeyer H.

    Genes Dev June 1, 2011 ; 25:1132-46 .

  • Regulator of Calcineurin 1 (RCAN1) Facilitates Neuronal Apoptosis through Caspase-3 Activation

    Sun X., Wu Y., Chen B., Zhang Z., Zhou W., Tong Y., Yuan J., Xia K., Gronemeyer H., Flavell R.A., Song W.

    J Biol Chem March 18, 2011 ; 286:9049-62 .

  • Retinoic acid receptor modulators: a perspective on recent advances and promises

    Alvarez S., Bourguet W., Gronemeyer H., de Lera A.R.

    Expert Opin Ther Pat Jan 2011 ; 21:55-63 .

  • Single-tube linear DNA amplification (LinDA) for robust ChIP-seq

    Shankaranarayanan P., Mendoza-Parra M.A., Walia M., Wang L., Li N., Trindade L.M., Gronemeyer H.

    Nat Methods 2011 ; 8:565-7 .

  • Targeted expression of tumor necrosis factor-related apoptosis-inducing ligand TRAIL in skin protects mice against chemical carcinogenesis

    Kedinger V., Muller S., Gronemeyer H.

    Mol Cancer 2011 ; 10:34 .

  • The 12th international conference on differentiation therapy: targeting the aberrant growth, differentiation and cell death programs of cancer cells

    Pettersson F., Miller W.H., Nervi C., Gronemeyer H.J., Licht J., Tallman M.S., Waxman S.

    Cell Death Differ Jul 2011 ; 18:1231-3 .

  • Total synthesis of the proposed structures of the DNA methyl transferase inhibitors peyssonenynes, and structural revision of peyssonenyne B

    Garcia-Dominguez P., Lepore I., Erb C., Gronemeyer H., Altucci L., Alvarez R., de Lera A.R.

    Org Biomol Chem Sept. 28, 2011 ; 9:6979-87 .

  • Towards novel paradigms for cancer therapy

    Pavet V., Portal M.M., Moulin J.C., Herbrecht R., Gronemeyer H.

    Oncogene Jan. 6, 2011 ; 30:1-20 .

  See all publications=>

• Job opportunities

  • Bioinformaticien En Recherche Sur Le Cancer H/F (H/F)
  • Phd - Equipe H.Gronemeyer (H/F)
  • Technicien H/F (H/F)