IGBMC : Institut de la Génétique et de la Biologie Moléculaire et Cellulaire

• Researchers

  Bohdan WASYLYK

• Post-Doctoral Fellowships

  Euan Douglas ROBERTSON

• Phd Students

  Pan LI

  Kostyantyn SEMENCHENKO

• Engineers & Technicians

  Christine WASYLYK

• Master Students

  David Nicolas MORAND

Functional genomics & cancer

Molecular and cellular biology of cancer

Increased understanding of biological pathways has led to the identification of particular processes that are usurped during the multistep development of human tumours. These processes include sustaining proliferative signalling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, and activating invasion and metastasis. Important roles are played by genomic instability, inflammation, altered energy metabolism, evasion of immune destruction, and the tumour microenvironment. However, we are still far from understanding the mechanisms sufficiently to rationalise normal biological processes and to identify key events that can be used to treat human cancer. Our objectives are to acquire knowledge about biological processes that are relevant to human cancer, and to use that knowledge to initiate translation to the clinic. We have focussed on novel genes that have not been described or analysed previously, in order to extend knowledge beyond the over-studied, popular highways of discovery.

• Current projects

  - FP7 Marie Curie ITN ProNest (Prostate Cancer)
  - INCa PLBIO2010 HypoNet
  - Ligue Nationale contre le Cancer Tumour Identity Card

• Collaborations

  1. Dr. J. Abecassis, Centre Paul Strauss, Strasbourg. I am a consultant for the Centre Paul Strauss. We collaborate in projects relating to HNSCC and the Ligue Carte d’Identité des Tumeurs. This includes the bioinformatics team CIT LNCLC, Paris; Rickman, de Reyniès A, Thomas E, Marisa L. We have collaborated in the identification of HNSCC markers, HPV in HNSCC, and are collaborate in the analysis of the genome, methylome and miRNAs in HNSCC.
  2. Members of the FP7 Marie Curie ProNest project. 19 laboratoires. The collaboration involves courses, seminars, discussions, meetings and materials (serum samples, grant applications). www.pro-nest.org/. We have projects in common with:
      a. Schalken Jack A. Prof. Dr. University Hospital Nijmegen, The Netherlands. (TTLL12 and XRP44X and ZG16b).
      b. Helmut KLOCKER PhD, University of Innsbruck Anichstr, Austria. (Prostate cancer IHC, TTLL12).
      c. Prof Gabri van der Pluijm, Leiden University Medical Center, The Netherlands (XRP44X and metastasis to the bone).
  3. Former lab members:
      a. K Nakade. Gene Engineering Division, BioResource Center, Japan. K Nakade is a former PhD student. We have collaborated on work related to JDB2.
      b. Ganguli-Indra G, Oregon State University, USA. She is a former PhD student and post-doc. After her move to Oregon, we collaborated in the analysis of CTIP2.
  4. Prof. Mary Waye Mary Miu Yee Waye (PhD), Professor, School of Biomedical Sciences, President, Hong Kong Society of Biochemistry and Molecular Biology, Founding Director, Croucher Laboratory for Human Genomics; The Chinese University of Hong Kong. Mentor of Weicheng Liang. Roles of miRNAs in the hypoxic response mediated by Elk3 and HIF1.
  5. For other collaborators, see our publications.

• Prizes/Awards

  • Bohdan WASYLYK - Member of the European Molecular Biology Organization (EMBO) - European Molecular Biology Organization (EMBO) - 1992

• News

• Publications

  • c-Jun N-terminal kinase mediates microtubule-depolymerizing agent-induced microtubule depolymerization and G2/M arrest in MCF-7 breast cancer cells.

    Chen J, Sun WL, Wasylyk B, Wang YP, Zheng H.

    Anticancer Drugs Jan 2012 ; 23:98-107 .

  • A review of post-translational modifications and subcellular localization of Ets transcription factors: possible connection with cancer and involvement in the hypoxic response

    Charlot C., Dubois-Pot H., Serchov T., Tourrette Y., Wasylyk B.

    Methods Mol Biol 2010 ; 647:3-30 .

  • ANO1 amplification and expression in HNSCC with a high propensity for future distant metastasis and its functions in HNSCC cell lines

    Ayoub C., Wasylyk C., Li Y., Thomas E., Marisa L., Robe A., Roux M., Abecassis J., de Reynies A., Wasylyk B.

    Br J Cancer Aug. 24, 2010 ; 103:715-26 .

  • Biological and clinical relevance of transcriptionally active human papillomavirus (HPV) infection in oropharynx squamous cell carcinoma

    Jung A.C., Briolat J., Millon R., de Reynies A., Rickman D., Thomas E., Abecassis J., Clavel C., Wasylyk B.

    Int J Cancer April 15, 2010 ; 126:1882-94 .

  • Involvement of net and Hif1alpha in distinct yet intricately linked hypoxia-induced signaling pathways

    Serchov T., Dubois-Pot-Schneider H., Charlot C., Rosl F., Wasylyk B.

    J Biol Chem July 9, 2010 ; 285:21223-32 .

  • Regulation of MCP-1 chemokine transcription by p53

    Hacke K., Rincon-Orozco B., Buchwalter G., Siehler S.Y., Wasylyk B., Wiesmuller L., Rosl F.

    Mol Cancer April 20, 2010 ; 9:82 .

  • Ternary complex factors SAP-1 and Elk-1, but not net, are functionally equivalent in thymocyte development

    Costello P., Nicolas R., Willoughby J., Wasylyk B., Nordheim A., Treisman R.

    J Immunol July 15, 2010 ; 185:1082-92 .

  • The expression of ELK transcription factors in adult DRG: Novel isoforms, antisense transcripts and upregulation by nerve damage

    Kerr N., Pintzas A., Holmes F., Hobson S.A., Pope R., Wallace M., Wasylyk C., Wasylyk B., Wynick D.

    Mol Cell Neurosci Jun 2010 ; 44:165-77 .

  • Tubulin tyrosine ligase like 12 links to prostate cancer through tubulin posttranslational modification and chromosome ploidy

    Wasylyk C., Zambrano A., Zhao C., Brants J., Abecassis J., Schalken J.A., Rogatsch H., Schaefer G., Pycha A., Klocker H., Wasylyk B.

    Int J Cancer Dec. 1, 2010 ; 127:2542-53 .

  • Complexity in transcription control at the activation domain-mediator interface

    Balamotis M.A., Pennella M.A., Stevens J.L., Wasylyk B., Belmont A.S., Berk A.J.

    Sci Signal 2009 ; 2:ra20 .

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