The Team
  • Researchers

    Pierre CHAMBON

    Mei LI

    Daniel METZGER

  • Post-Doctoral Fellowships

    Manohar DAMARA

    Guoqiang HUA

    Gilles LAVERNY

    Nisha MISRA

    Atish MUKHERJI

    Maxime PARISOTTO

  • Phd Students

    Yongyuan DAI

    Carole EL HACHEM

    Ahmad KOBIITA

    Jiagui LI

    Vanessa UEBERSCHLAG-PITIOT

    Ruicheng WEI

  • Engineers & Technicians

    Jean-Marc BORNERT

    Pierre HENER

    Magali HUC

    Laetitia PAULEN

Functional genomics and cancer

Pathophysical function of nuclear receptor signaling

The last decade has seen an enormous rise in the interest for nuclear receptors (NRs), because of their central role in the coordination of development and homeostasis, through their ability to transduce hormonal signals into modulation of gene activity. Our main goal is to study, under physiological and pathophysiological conditions in the whole organism, the function and interdependence of signaling pathways that are regulated by various nuclear receptors [e.g. the retinoid X receptors (RXRs), the retinoic acid receptors (RARs), the peroxisome proliferator-activated receptors (PPARs), the vitamin D3 receptor (VDR), the oestrogen receptors (ERs), the androgen receptor (AR) and the glucocorticoid receptor (GR)] in different organs (e.g. skin, lung, intestine, skeletal muscle and reproductive organs). In that respect, we have used our site-directed cell-specific temporally-controlled somatic mutagenesis method, which allows the generation of somatic mutations in the mouse of any given gene, at any chosen time and in any specific cell type. Interestingly, as this genetic tool is also of great value to generate mouse models of human cancers, the knowledge gained from their analyses should contribute to the development of new cancer therapies.

Imprimer Envoyer

Université de Strasbourg
INSERM
CNRS

IGBMC - CNRS UMR 7104 - Inserm U 964
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