The Team
  • Researchers

    Marat YUSUPOV

  • Post-Doctoral Fellowships

    Adam BEN SHEM

    Yuzuru ITOH

    Justine MAILLIOT

    Sergey MELNIKOV

    Mélanie MEYER

    Simone PELLEGRINO

  • Phd Students

    David BRUCHLEN

Integrated structural Biology

Ribosomes

The ribosome is a large ribo-nucleoprotein complex with total molecular mass of 2 500 000 Dalton in bacteria and 3 300 000 Dalton in yeast. Several components contribute to the greater weight and complexity of eukaryotic ribosomes: RNA expansion segments that are inserted into the evolutionary conserved rRNA core and additional 25 proteins. The ribosome performs protein synthesis using a messenger RNA template. It mediates the interactions between mRNAs and tRNAs and it catalyses the peptide bond formation. Our group has developed methods for x-ray study of bacterial 70S ribosome from the extreme thermophilic microorganism Thermus thermophilus and recently for the 80S ribosome from the yeast Saccharomyces cerevisiae. The goal of our group is to study structure and mechanism of protein biosynthesis in bacteria, yeast and humans.

Imprimer Envoyer

Université de Strasbourg
INSERM
CNRS

IGBMC - CNRS UMR 7104 - Inserm U 964
1 rue Laurent Fries / BP 10142 / 67404 Illkirch CEDEX / France Tél +33 (0)3 88 65 32 00 / Fax +33 (0)3 88 65 32 01 / directeur.igbmc@igbmc.fr